First reported by NBC, a Malaysia Airlines 777-200 en route from Kuala Lumpur to Beijing has lost radio contact. Though there is no confirmation that the aircraft has indeed crashed, it's never a good sign of course. There are 239 (227 pax, 12 crew) souls on board and the flight was scheduled to land at PEK at 0630 local time (1730 Eastern Time). The flight number is MH370.
Here's to hoping it's just a bit of radio trouble, though I fear that's unlikely.